Experimental studies on the specificity of skin tests for the diagnosis of schistosomiasis

TitleExperimental studies on the specificity of skin tests for the diagnosis of schistosomiasis
Publication TypeJournal Article
Year of Publication1949
AuthorsAugustine DL, Weller TH
JournalJournal of Parasitology
Volume35
Issue5
Pagination461-466
KeywordsTESTING
Abstract

Rabbits were repeatedly exposed to three species of non-human schistosome cercariae, C. stagnicolae, C. physellae, and C. elvae, with the production, after the first exposure, of an extensive dermatitis. Approximately seven weeks after the last exposure, intradermal tests were performed on the 5 experimental and 2 control rabbits, using antigens made from the 3 non-human schistosome cercariae, two different antigens prepared from cercariae of Schistosoma mansoni, and an antigen made from cercariae of a strigeid, D. flexicaudum. Essentially negative reactions were obtained with the two Schistosoma mansoni antigens when employed in high dilutions. The results obtained with the other antigens were equivocal. An effective method for the concentration of living dermatitis-producing schistosome cercariae was developed by utilizing the positive phototropic and negative geotropic reactions of the cercariae.